University : Flinders University
Course Title : BIOL3771
Uploaded by : Mark polee
Answer:
miR-7 is a class of short non-coding regulatory micro RNAs, which plays major role in controlling the post-transcriptional expression of mRNA. miR-7 is crucial for insulin expression as studied in mice. It can cause impairment of insulin secretion in the pancreatic islet cells causing diabetes when overexpressed in mice (Hansen et al. 2013). It is reported in several studies that miR-7 might enact in suppressing progress of cancer in pancreatic cells, lung cells, breast, and also in neuronal cells. The inhibitory regulation of miR-7 is therapeutically introduced to fight cancer nowadays. Circular RNAs are another class of regulatory RNAs. Relative expression level of miR-7 is lower in tumour cells than surrounding normal cells and cancer patients with high expression of miR-7 has better survivality, so the expression of miR-7 can be used as a molecular biomarker to predict average survival rate in cancer patients (Cheng et al. 2017). A hum....